NCCN Guidelines® Insights: Squamous Cell Skin Cancer, Version 1.2022

Area of Science:

• Oncology
• Dermatology

Background:

• Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer.
• The NCCN Guidelines provide essential recommendations for cSCC management.
• Regular guideline updates are crucial for incorporating the latest evidence.

Purpose of the Study:

• To summarize recent updates to the NCCN Guidelines for Squamous Cell Skin Cancer.
• To highlight key changes in diagnostic and treatment recommendations.
• To inform clinicians about advancements in cSCC care.

Main Methods:

• Annual review of NCCN Guidelines by a multidisciplinary panel.
• Inclusion of public and institutional comments and submissions.
• Focus on specific updates in surgical terminology, topical prophylaxis, immunotherapy, and radiation therapy.

Main Results:

• Introduction of new terminology for surgical margin assessment: peripheral and deep en face margin assessment.
• Updated recommendations for topical prophylaxis strategies.
• Recent advancements in immunotherapy for regional and metastatic cSCC.
• Refined approaches to radiation therapy for cSCC treatment.

Conclusions:

• The updated NCCN Guidelines offer refined strategies for cSCC diagnosis and management.
• New surgical terminology enhances precision in treatment planning.
• Recent advancements in immunotherapy and radiation therapy provide more effective options for advanced disease.