Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

189
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
189
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Personalizing post-treatment cancer care: a cross-sectional survey of the needs and preferences of well survivors of breast cancer.

Current oncology (Toronto, Ont.)·2019
Same author

Outcomes in Patients Treated with Post-mastectomy Chest Wall Radiotherapy without the Routine Use of Bolus.

Clinical oncology (Royal College of Radiologists (Great Britain))·2018
Same author

Prognostic Significance of Human Papilloma Virus and p16 Expression in Patients with Vulvar Squamous Cell Carcinoma who Received Radiotherapy.

Clinical oncology (Royal College of Radiologists (Great Britain))·2018
Same author

Clinical consequences of upfront pathology review in the randomised PORTEC-3 trial for high-risk endometrial cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?

American journal of surgery·2017
Same author

Building a New Model of Care for Rapid Breast Radiotherapy Treatment Planning: Evaluation of the Advanced Practice Radiation Therapist in Cavity Delineation.

Clinical oncology (Royal College of Radiologists (Great Britain))·2016
Same journal

Research Trends in Physical Activity and Breast Cancer: A 25-Year Bibliometric Analysis (2000-2025).

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Concordance Between Planned and Delivered treatment for Head and Neck Cancer Patients Treated With Curative Intent: A Real-World Comparison of Under 70-year-olds With 70-year-olds and Over.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

A Novel Technique for Pain Management to Deliver a Course of Palliative Radiotherapy.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Broad-Spectrum Antibiotics are Associated with worse Survival After Radical Treatment for Glioblastoma Multiforme: A Multicentre Study.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Exploring the Need for Plan Adaptation in Robustly Optimised Head and Neck Intensity Modulated Proton Therapy: A Dosimetric Perspective From Initial Institutional Experience.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Lifting the Lid on Best Practice in a Case of Oligometastatic Breast Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
See all related articles

Related Experiment Video

Updated: Oct 10, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.6K

Radiotherapy Quality Assurance in the PORTEC-3 (TROG 08.04) Trial.

P Khaw1, V Do2, K Lim2

  • 1Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; University of Melbourne, Melbourne, Victoria, Australia.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|December 14, 2021
PubMed
Summary
This summary is machine-generated.

Quality assurance in radiotherapy (QART) for the PORTEC-3 trial demonstrated high uniformity in contouring and dosimetry. This confirms the safe implementation of this endometrial cancer treatment protocol in clinical practice.

Keywords:
PORTEC-3Quality assurance in radiotherapy

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.9K
Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.6K

Related Experiment Videos

Last Updated: Oct 10, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.6K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.9K
Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.6K

Area of Science:

  • Oncology
  • Radiation Oncology
  • Clinical Trials

Background:

  • Quality assurance in radiotherapy (QART) is crucial for maintaining the scientific integrity of clinical trials.
  • The PORTEC-3 trial investigated the efficacy of pelvic radiotherapy with concurrent chemoradiotherapy followed by adjuvant chemotherapy for high-risk endometrial cancer, demonstrating an overall survival benefit.

Purpose of the Study:

  • To report the findings of a retrospective QART assessment for all participating centers in the PORTEC-3 trial.
  • To evaluate the uniformity and accuracy of contouring and dosimetry across trial sites.

Main Methods:

  • Clinicians uploaded anonymized patient cases for analysis.
  • Panel reviewers assessed target volumes and organs at risk for adherence to guidelines.
  • Radiotherapy plans underwent dosimetric evaluation using the Trans-Tasman Radiation Oncology Group (TROG) protocol.

Main Results:

  • Data from 146 patients across 87 centers were reviewed between August 2010 and January 2018.
  • Out of 3514 reviewed variables, 89.2% were acceptable, with 9.6% minor and 1.2% major variations.
  • Major contour variations were identified in the vaginal vault, parametria, and vault expansion.

Conclusions:

  • The QART assessment revealed high uniformity and low rates of deviations in contouring and dosimetry.
  • These findings support the safe integration of the PORTEC-3 treatment protocol into routine clinical practice.