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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
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Right ventricular function in β-thalassemia children: comparing three-dimensional echocardiography with other
Eslam E Elhawary1, Osama A Tolba2, Asmaa A Elkaffas3
1Hematology and Bone Marrow Transplantation Unit, Pediatrics Department, Faculty of Medicine, Tanta University, Tanta, Egypt. eslam.elhawary@med.tanta.edu.eg.
Pediatric Research
|December 14, 2021
Summary
Children with beta-thalassemia major show reduced right ventricle function before symptoms appear. Advanced echocardiography can detect this early, enabling timely intervention and improved outcomes for pediatric patients.
Area of Science:
- Cardiology
- Pediatrics
- Hematology
Background:
- Cardiomyopathy is a significant complication in beta-thalassemia major (β-TM), impacting mortality and morbidity.
- Early detection of cardiac issues in β-TM is crucial for effective management.
Purpose of the Study:
- To assess right ventricle (RV) function in asymptomatic children with β-TM using 3D echocardiography.
- To compare RV functional parameters with other established echocardiographic measures.
Main Methods:
- A cohort study involving 50 children with β-TM and 50 healthy controls.
- Evaluation of RV function using 2D-RV FAC, 3D-RVEF, TAPSE, TDI, MPI, and 2D-STE (including LSS, SSR, DSR E, DSR A).
Main Results:
- Significant differences in 3D-RVEF, MPI, and 2D-STE parameters were observed between β-TM patients and controls.
- ROC curve analysis indicated fair discriminatory power (AUC > 0.7) for detecting RV dysfunction.
Conclusions:
- β-TM patients exhibit diminished RV function indices in the pre-symptomatic stage.
- Early detection of subclinical RV dysfunction is feasible using advanced echocardiographic techniques, facilitating closer monitoring and intervention.
