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Related Experiment Video

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A primate temporal cortex-zona incerta pathway for novelty seeking.

Takaya Ogasawara1, Fatih Sogukpinar2, Kaining Zhang3

  • 1Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA. takaya.ogasawara@wustl.edu.

Nature Neuroscience
|December 14, 2021
PubMed
Summary

The study reveals the zona incerta (ZI) regulates novelty seeking in primates. ZI stimulation aids exploration, while inactivation reduces it, uncovering a novel brain pathway for visual object exploration.

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Area of Science:

  • Neuroscience
  • Primate Behavior
  • Visual Cognition

Background:

  • Primates actively explore visual objects, driven by novelty.
  • The neural mechanisms controlling this intrinsic motivation remain largely unknown.

Purpose of the Study:

  • To investigate the neural basis of novelty seeking in primates.
  • To identify brain regions regulating the exploration of novel visual objects.

Main Methods:

  • Recorded neuronal activity in the zona incerta (ZI) during visual exploration tasks in monkeys.
  • Manipulated ZI activity using low-intensity stimulation and inactivation.
  • Examined the role of the anterior ventral medial temporal cortex in novelty prediction.

Main Results:

  • Zona incerta (ZI) neurons showed preferential activation preceding gaze shifts towards novel objects.
  • ZI stimulation facilitated, while inactivation suppressed, novelty-seeking behavior.
  • Novelty prediction originated from the anterior ventral medial temporal cortex, not traditionally associated reward pathways.

Conclusions:

  • The zona incerta (ZI) plays a critical role in regulating primate novelty seeking.
  • A distinct neural pathway involving the ZI and anterior ventral medial temporal cortex underlies exploration of novel visual stimuli.
  • This pathway operates independently of traditional reward-seeking circuits.