Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

8.2K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implications of Cranial Arterial Stenosis and Dolichoectasia for Cerebral Small-Vessel Disease Etiopathogenesis: Findings From a Prospective Mild Stroke Cohort.

Circulation·2026
Same author

Near-peer learning in neurology residency: a 6-year experience comparing knowledge gains across cerebrovascular, electromyography, and electroencephalography modules.

BMC medical education·2026
Same author

Development and internal validation of a spatiotemporal gait parameter-based diagnostic model for cerebral small vessel disease.

Frontiers in aging neuroscience·2026
Same author

Cerebral small vessel disease burden relates to cognitive decline via impaired amyloid clearance in the general population.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Choroid plexus enlargement is associated with poor functional status in cerebral small vessel disease via reduced DTI-ALPS index: a 5T MRI study.

Quantitative imaging in medicine and surgery·2026
Same author

Different Characteristics of Incidental Diffusion-Weighted Imaging-Positive Lesions and Recent Small Subcortical Infarct in Patients With Cerebral Small Vessel Disease.

Journal of the American Heart Association·2026

Related Experiment Video

Updated: Oct 10, 2025

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.0K

Migraine and Ischemic Stroke: A Mendelian Randomization Study.

Mei-Jun Shu1, Jia-Rui Li2, Yi-Cheng Zhu1

  • 1Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing, Beijing, 10073, China.

Neurology and Therapy
|December 14, 2021
PubMed
Summary
This summary is machine-generated.

This study found no causal link between migraine and ischemic stroke or its subtypes. Mendelian randomization analysis of genetic data did not support a causal relationship, strengthening evidence for independent conditions.

Keywords:
Ischemic strokeMendelian randomizationMigraineStroke

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.4K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

8.6K

Related Experiment Videos

Last Updated: Oct 10, 2025

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.0K
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.4K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

8.6K

Area of Science:

  • Neuroscience
  • Genetics
  • Epidemiology

Background:

  • Previous studies suggest a link between migraine and increased ischemic stroke risk.
  • However, robust evidence for a causal relationship is limited.
  • This study investigates the potential causal link between migraine and ischemic stroke, including its subtypes.

Purpose of the Study:

  • To explore the potential causal relationship between migraine and ischemic stroke.
  • To investigate the causal association with specific ischemic stroke subtypes: large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES).

Main Methods:

  • Utilized genome-wide association study (GWAS) data for migraine in European ancestries.
  • Employed two-sample Mendelian randomization (MR) analysis with inverse-variance-weighted method.
  • Conducted sensitivity analyses using MR-Egger, weighted median, and other methods for robustness.

Main Results:

  • No statistically significant causal association was detected between migraine and overall ischemic stroke (P=0.159).
  • Similarly, no significant causal links were found for large artery stroke (P=0.018), small vessel stroke (P=0.460), or cardioembolic stroke (P=0.850).
  • Sensitivity analyses confirmed the consistency of these findings.

Conclusions:

  • This Mendelian randomization study provides evidence against a causal effect of migraine on ischemic stroke.
  • The findings suggest that migraine and ischemic stroke may be independent conditions.
  • Further research may explore shared risk factors or alternative biological pathways.