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Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence

Zinat Heidari1, Maryam Daei2, Motahareh Boozari3

  • 1Department of Clinical Pharmacy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Phytotherapy Research : PTR
|December 14, 2021
PubMed

Insights

Curcumin supplementation appears safe for children and may improve inflammatory, immune, and metabolic disorders. However, more research is needed for other conditions like ADPKD, CF, TOF, and infections.

Area of Science:

  • Pediatric Medicine
  • Pharmacology
  • Natural Product Research

Background:

  • Curcumin, a compound from turmeric, has demonstrated anti-inflammatory and antioxidant properties.
  • Pediatric use of curcumin is gaining interest for various health conditions.
  • Systematic reviews are crucial for evaluating the efficacy and safety of supplements in children.

Purpose of the Study:

  • To systematically review clinical trials on curcumin supplementation in pediatric patients.
  • To assess the clinical efficacy and safety of curcumin in children with diverse health conditions.
  • To identify gaps in current research and guide future studies.

Main Methods:

  • Systematic search of major electronic databases (PubMed, EMBASE, Web of Science, Scopus).
  • Inclusion of all clinical trials investigating curcumin in the pediatric population.
  • Identification and analysis of 16 relevant studies.

Main Results:

  • Curcumin was generally well-tolerated across all included studies.
  • Evidence suggests curcumin improved inflammatory, immune, and metabolic disorders in children.
  • Efficacy remains unclear for autosomal dominant polycystic kidney disease (ADPKD), cystic fibrosis (CF), tetralogy of Fallot (TOF), and infectious diseases.

Conclusions:

  • Curcumin supplementation shows promise for certain pediatric conditions, particularly inflammatory, immune, and metabolic disorders.
  • Further large-scale, randomized, placebo-controlled trials are necessary to confirm efficacy and safety.
  • Heterogeneity in study designs, doses, and populations limits current quantitative analysis.

Keywords:
clinical trialcurcuminefficacypediatricsafety

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