Related Experiment Video
Updated: Oct 10, 2025

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma
Hervé Tilly1, Franck Morschhauser1, Laurie H Sehn1
1From the Department of Hematology and INSERM Unité 1245, Centre Henri-Becquerel and University of Rouen, Rouen (H.T.), Université de Lille, Centre Hospitalier Universitaire (CHU) Lille, ULR 7365 - GRITA - Groupe de Recherche sur les Formes Injectables et les Technologies Associées, Lille (F.M.), CHU de Montpellier, Montpellier (C.H.), the Department of Hematology, Institut Universitaire du Cancer, Toulouse-Oncopole, Toulouse (L.O.), and the Department of Hematology, Centre Hospitalier Régional Universitaire - Besançon, Besançon (A.C.) - all in France; the Centre for Lymphoid Cancer at BC Cancer and the University of British Columbia, Vancouver (L.H.S.), the Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto (M.C.C.), and F. Hoffmann-La Roche, Mississauga, ON (M.Y.) - all in Canada; the Wilmot Cancer Institute, University of Rochester, Rochester (J.W.F.), and Memorial Sloan Kettering Cancer Center, New York (M.M., G.S.) - both in New York; the First Faculty of Medicine, Charles University and the General University Hospital, Prague, Czech Republic (M.T.); the Willamette Valley Cancer Institute and Research Center, the US Oncology Network, Eugene, OR (J.P.S.); Rocky Mountain Cancer Centers, Aurora, CO (J.M.B.); Memorial Sloan Kettering Cancer Center, Montvale, NJ (M.M.); the Department of Hematology and Rheumatology, Kindai University, Faculty of Medicine, Osaka-Sayama City (S.R.), and the National Cancer Center Hospital, Tokyo (K.I.) - both in Japan; Washington University in St. Louis, St. Louis (N.M.-S.); the Maria Sklodowska-Curie National Research Institute of Oncology, Krakow, Poland (W.J.); Peking University Cancer Hospital, Beijing (Y.S.); the 3rd Medical Department, Paracelsus Medical University, Salzburg Cancer Research Institute-Center for Clinical Cancer and Immunology Trials, and Cancer Cluster Salzburg, Salzburg, Austria (R.G.); the Feofaniya Clinical Hospital, Kyiv, Ukraine (L.M.); Hospital San Pedro de Alcántara, Cáceres (J.M.B.-B.), and the Department of Hematology, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona (P.A.) - both in Spain; the Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione G. Pascale, IRCCS, Naples, Italy (A.P.); the Division of Hematology-Oncology, Department of Internal Medicine, Research Institute of Medical Science, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea (H.-J.S.); Princess Alexandra Hospital, Brisbane, QLD, Australia (G.H.); Hospital Erasto Gaertner, Curitiba, Brazil (E.M.); Taipei Veterans General Hospital, Taipei, Taiwan (J.-P.G.); Genentech, South San Francisco, CA (J.H., Y.J., C.L.); and M.D. Anderson Cancer Center, Houston (C.R.F.).
Polatuzumab vedotin combined with R-CHOP (pola-R-CHP) improved progression-free survival in previously untreated diffuse large B-cell lymphoma (DLBCL) patients compared to standard R-CHOP. Overall survival and safety profiles were similar between the two treatments.
Area of Science:
- Hematology
- Oncology
- Clinical Trials
Background:
- Diffuse large B-cell lymphoma (DLBCL) treatment relies on R-CHOP, but cure rates are limited to 60% of patients.
- Polatuzumab vedotin, an antibody-drug conjugate targeting CD79b, offers a novel therapeutic approach for malignant B cells.
Purpose of the Study:
- To evaluate the efficacy and safety of a modified R-CHOP regimen (pola-R-CHP) versus standard R-CHOP in previously untreated DLBCL patients.
- To assess the impact of replacing vincristine with polatuzumab vedotin on progression-free survival and overall survival.
Main Methods:
- A double-blind, placebo-controlled, international phase 3 trial (POLARIX) was conducted.
- 879 patients with intermediate- or high-risk DLBCL were randomized 1:1 to receive either pola-R-CHP or R-CHOP, followed by rituximab.
- Progression-free survival (PFS) was the primary endpoint, with overall survival and safety as secondary endpoints.
Main Results:
- Pola-R-CHP demonstrated a significantly higher 2-year progression-free survival rate (76.7%) compared to R-CHOP (70.2%), with a hazard ratio of 0.73 (P=0.02).
- Overall survival at 2 years did not significantly differ between the groups (88.7% for pola-R-CHP vs. 88.6% for R-CHOP).
- The safety profiles of both treatment regimens were comparable.
Conclusions:
- The modified pola-R-CHP regimen significantly reduced the risk of disease progression, relapse, or death in previously untreated DLBCL patients compared to standard R-CHOP.
- Pola-R-CHP represents a promising new treatment option for DLBCL, offering improved disease control without compromising safety.
More Related Videos
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
09:44Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
Related Concept Videos
Treatment Resistant Cancers
Tumor Immunotherapy
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Targeted Cancer Therapies
There are several types of targeted therapies against...