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Recent advances in palladium-catalyzed C(sp3)/C(sp2)-H bond functionalizations: access to C-branched glycosides
Zanjila Azeem1,2, Pintu Kumar Mandal1,2
1Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extn, Sitapur Road, P.O. Box 173, Lucknow 226031, India. pintuchem06@gmail.com.
Abstract:
Over the recent decades, tremendous interest has developed in the transformation of complex substrates by C-H activation and functionalization. In particular, palladium-catalyzed directing and non-directing group-assisted C-H functionalization has emerged as a powerful avenue to access C-branched glycosides. Due to the extreme complexity, delicate functionalities, and high stability of C-H bonds, site-selective functionalization of carbohydrate under mild conditions is highly desirable. The purpose of this review is to cover most of the recent advances in palladium-catalyzed C(sp3) and C(sp2)-H bond functionalizations for the synthesis of C-branched glycosides along with future directions.
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