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Updated: Oct 10, 2025
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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[Inappropriate systemic therapy in severe atopic dermatitis-severe long-term damage]
F Abeck1, N Booken2, S Schneider2
1Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland. finn.abeck@uke.de.
Dermatologie (Heidelberg, Germany)
|December 14, 2021
Summary
Severe atopic dermatitis treatment improved with biologics like dupilumab. A patient with side effects from long-term glucocorticoids was switched to guideline-based dupilumab therapy.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Severe atopic dermatitis treatment options were historically limited.
- The approval of dupilumab in 2017 marked a significant advancement.
- Newer systemic therapies include tralokinumab and Janus kinase inhibitors.
Observation:
- A 28-year-old patient experienced severe side effects from long-term systemic glucocorticoid use.
- This case highlights instances where modern treatment options are overlooked.
- The patient required comprehensive assessment of treatment-related damage.
Findings:
- Guideline-based therapy with dupilumab was initiated for the patient.
- Interdisciplinary collaboration was established with specialists including endocrinologists, ophthalmologists, osteologists, and nutritionists.
- This approach addresses complex patient needs beyond standard dermatological care.
Implications:
- Advances in biologic and targeted therapies are transforming severe atopic dermatitis management.
- Systemic glucocorticoids carry significant risks for long-term use in atopic dermatitis.
- Multidisciplinary care is crucial for managing complex cases and optimizing outcomes with new therapies.
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