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Advanced nanoengineered-customized point-of-care tools for prostate-specific antigen
Arshid Numan1, Sima Singh2,3, Yiqiang Zhan4
1Graphene & Advanced 2D Materials Research Group (GAMRG), School of Engineering and Technology, Sunway University, No. 5, Jalan Universiti, Bandar Sunway, 47500, Petaling Jaya, Selangor, Malaysia.
Mikrochimica Acta
|December 14, 2021
Summary
Developing advanced nanotechnology-based tools for prostate cancer (PCa) diagnosis offers low-cost, real-time detection of prostate-specific antigen (PSA) at the point-of-care (POC). This approach aims to overcome limitations of current screening methods for improved PCa management.
Area of Science:
- Biomedical Engineering
- Materials Science
- Cancer Biology
- Nanotechnology
Background:
- Prostate cancer (PCa) progression is linked to changes in human prostate-specific antigen (PSA) levels.
- Current PSA screening methods face limitations including cost, assay time, and accuracy.
- There is a need for innovative, accessible diagnostic tools for PCa.
Purpose of the Study:
- To review advancements in integrating engineering sciences with cancer biology for PCa diagnosis.
- To explore the potential of nanotechnology-based tools for point-of-care (POC) detection of PSA.
- To highlight the prospects and challenges in developing high-performance POC devices for PCa.
Main Methods:
- Review of current literature on nanotechnology applications in PCa diagnostics.
- Analysis of engineering and materials science approaches for PSA detection.
- Focus on point-of-care (POC) diagnostic techniques and sensor development.
Main Results:
- Nanotechnology integration offers promising solutions for quantitative and real-time PSA detection.
- Emerging POC diagnostic techniques enable low-cost, user-friendly sensor devices.
- Engineering and materials science advancements are crucial for developing sensitive PCa detection tools.
Conclusions:
- Nanotechnology-based POC devices hold significant potential for early and accessible PCa diagnosis.
- Overcoming current screening limitations requires interdisciplinary collaboration.
- Further development of novel nanomaterials is essential for high-performance PCa detection systems.
