Maternal Duplication 15q11-13 Syndrome with Autism Spectrum Disorder: Mood Stabilization by Carbamazepine
Christopher George Viamontes1, Jorge Castillo Gonzalez1, Fedra Najjar1
1Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Journal of Child and Adolescent Psychopharmacology
|December 14, 2021
Summary
Carbamazepine effectively managed mood symptoms and seizures in patients with 15q11-13 duplication syndrome (dup15q) and autism spectrum disorder (ASD). This medication showed superior mood stabilization compared to other treatments in a small patient group.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Maternal 15q11-13 duplication syndrome (dup15q) is a frequent genetic cause of autism spectrum disorder (ASD).
- Patients with dup15q often experience psychiatric symptoms and seizures.
- Carbamazepine is used for seizures in dup15q but not established as a mood stabilizer.
Purpose of the Study:
- To evaluate carbamazepine's efficacy as a mood stabilizer in patients with dup15q and ASD.
- To compare carbamazepine's effectiveness against other mood stabilizers in this population.
Main Methods:
- Retrospective chart review of five consecutive patients with dup15q and ASD.
- Patients received carbamazepine for psychiatric symptoms and/or seizures.
- Comparison of carbamazepine's efficacy with previously used mood stabilizers.
Main Results:
- Carbamazepine improved mood-related symptoms (hyperactivity, impulsivity, irritability, mood lability) in all five patients.
- Carbamazepine was more effective than oxcarbazepine, valproate, and lamotrigine.
- Carbamazepine demonstrated better seizure control in one patient; valproate worsened symptoms in another.
- Anxiety symptoms improved with carbamazepine in three patients.
Conclusions:
- Carbamazepine appears to be an effective mood stabilizer for psychiatric symptoms in patients with dup15q and ASD.
- Further investigation through prospective randomized controlled trials is warranted to confirm these findings.
Keywords:
Dup15qautism spectrum disorderbipolar disordercarbamazepinematernal duplication 15q11-q13 syndromemood stabilizationMore Related Videos
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