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New compounds from Sarcophyton glaucom-derived Penicillium sp
1Chemistry of Natural Compounds Department, Division of Pharmaceutical Industries, National Research Centre, El-Behoos St. 33, Dokki, Cairo 12622, Egypt.
Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|December 14, 2021
Summary
Researchers discovered five new bioactive compounds from a Penicillium fungus derived from soft coral. These compounds, along with six known ones, were analyzed for their antimicrobial properties.
Area of Science:
- Marine Natural Products Chemistry
- Microbial Metabolomics
- Drug Discovery
Background:
- Soft corals are a rich source of bioactive secondary metabolites.
- Fungi associated with marine organisms can produce novel chemical entities.
Purpose of the Study:
- To isolate and characterize new bioactive compounds from a soft coral-derived fungus.
- To evaluate the antimicrobial potential of the isolated compounds.
Main Methods:
- Spectroscopic techniques including 1D and 2D NMR (1H-1H COSY, HMBC, NOESY) and High-Resolution Electrospray Ionization Mass Spectrometry (HRESIMS).
- Chemical isolation and purification of fungal metabolites.
- Antimicrobial activity assays.
Main Results:
- Five new compounds (9-methoxy-penicyrone A, 9-methoxy-penicyrone B, and three esters) were identified.
- Six known compounds, including penicyrones A-B, were also isolated.
- The structural elucidation of new compounds was confirmed through comprehensive spectroscopic analysis.
Conclusions:
- The study expands the known chemical diversity of fungal metabolites from marine sources.
- The isolated compounds represent potential leads for antimicrobial drug development.
