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Updated: Oct 10, 2025

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
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Tear-Based Vibrational Spectroscopy Applied to Amyotrophic Lateral Sclerosis

Diletta Ami1, Alessandro Duse2,3, Paolo Mereghetti4

  • 1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.

Analytical Chemistry
|December 14, 2021
PubMed
Summary

Tear analysis using vibrational spectroscopy offers a new, non-invasive method for diagnosing amyotrophic lateral sclerosis (ALS). This technique accurately distinguishes ALS patients from healthy individuals by detecting unique spectroscopic markers in tears.

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