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Updated: Oct 10, 2025
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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
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Calcium and vitamin D supplementation: when and why
Camilla Benini1, Daniele Esposito1, Giovanni Adami1
1Unit of Rheumatology, University of Verona, Verona, Italy.
Minerva Obstetrics and Gynecology
|December 15, 2021
Summary
Calcium and vitamin D are crucial for bone health, and supplementation is effective for those with insufficient intake. Addressing deficiencies is vital for preventing osteoporosis complications and reducing health burdens.
Area of Science:
- Nutritional Science
- Gerontology
- Public Health
Background:
- Osteoporosis leads to fragility fractures, posing a significant health burden.
- Calcium and vitamin D are vital for bone health but play distinct metabolic roles.
- Deficiencies in calcium and vitamin D are prevalent globally, impacting skeletal and extra-skeletal health.
Purpose of the Study:
- To review calcium and vitamin D intake.
- To discuss the role of calcium and vitamin D supplementation.
- To highlight the importance of adequate levels for bone health and preventing complications.
Main Methods:
- This narrative review synthesizes existing literature on calcium and vitamin D.
- It examines dietary intake, deficiency prevalence, and supplementation efficacy.
- Focuses on the distinct roles of calcium and vitamin D in mineral metabolism.
Main Results:
- Insufficient calcium intake and vitamin D deficiency are widespread.
- Supplementation strategies are effective and safe when dietary intake is inadequate.
- Vitamin D deficiency is linked to various extra-skeletal health issues.
Conclusions:
- Adequate calcium intake and vitamin D serum levels are essential for the general population.
- Targeted supplementation is recommended for individuals at risk of deficiency.
- Addressing deficiencies is critical for managing osteoporosis and its complications.
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