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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Creative regulatory practices to develop stem-cell technology: the way forward for Malaysia.

Mohammad Firdaus Bin Abdul Aziz1,2, Michael Morrison2, Jane Kaye2

  • 1Centre for Law and Ethics in Science and Technology (CELEST), Faculty of Law, Universiti Malaya, Kuala Lumpur, Malaysia.

Regenerative Medicine
|December 15, 2021
PubMed
Summary

Malaysia aims to advance regenerative medicine using stem-cell technology. A comparative legal analysis suggests adopting a hybrid regulatory approach, blending various mechanisms to foster innovation and prevent unethical practices for future industry success.

Keywords:
CommonwealthMalaysiaethicsinnovationregenerative medicineregulationstem cells

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Area of Science:

  • Biotechnology
  • Medical Law
  • Public Policy

Background:

  • Malaysia seeks to establish a robust regenerative medicine sector driven by stem-cell technology.
  • Effective regulation is crucial for both facilitating scientific advancement and preventing unethical practices in stem-cell research.
  • Existing regulatory frameworks in experienced Commonwealth nations offer insights into managing this complex field.

Purpose of the Study:

  • To conduct a comparative legal analysis of stem-cell technology regulations.
  • To examine regulatory mechanisms in Malaysia and selected Commonwealth countries.
  • To propose an optimal regulatory strategy for Malaysia's regenerative medicine aspirations.

Main Methods:

  • Comparative legal analysis of regulatory frameworks.
  • Focus on stem-cell research and regenerative medicine policies.
  • Review of selected Commonwealth countries with established regulatory experience.

Main Results:

  • Selected Commonwealth countries employ a hybrid regulatory approach, combining diverse mechanisms.
  • These hybrid systems aim to balance innovation promotion with ethical oversight.
  • Malaysia's current regulatory landscape may benefit from adopting similar multifaceted strategies.

Conclusions:

  • Malaysia should consider a hybrid regulatory model for stem-cell technology.
  • This approach can empower authorities to foster innovation and prevent misconduct.
  • Adopting such a strategy is vital for cultivating a successful regenerative medicine industry and achieving national aspirations.