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Updated: Oct 10, 2025

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
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Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

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Novel LTBP3 mutations associated with thoracic aortic aneurysms and dissections

Guoyan Zhu1, Mingyao Luo2, Qianlong Chen1

  • 1State Key Laboratory of Cardiovascular Disease, Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, Diagnostic Laboratory Service, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

Orphanet Journal of Rare Diseases
|December 15, 2021
PubMed
Summary

Genetic analysis identified new mutations in the LTBP3 gene in patients with thoracic aortic aneurysm and dissection (TAAD). This finding expands the known genetic causes of TAAD and suggests LTBP3 should be included in routine genetic testing for the condition.

Keywords:
Genetic mutationLTBP3 geneThoracic aortic aneurysm and dissection

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