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Gout and the COVID-19 pandemic

Vicky Tai1, Philip C Robinson2,3, Nicola Dalbeth1

  • 1Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Current Opinion in Rheumatology
|December 15, 2021
PubMed

Insights

People with gout face higher risks from COVID-19 due to existing conditions and inflammation. Gout treatments like colchicine show potential for COVID-19, but the pandemic negatively impacted gout care.

Area of Science:

  • Rheumatology and Infectious Diseases
  • Immunology and Inflammation

Background:

  • Gout patients may experience worse COVID-19 outcomes due to cardiometabolic comorbidities.
  • Chronic hyperuricemia and gout-induced inflammation can influence COVID-19 severity.
  • Glucocorticoid use for gout flares might negatively affect COVID-19 outcomes and vaccine response.

Purpose of the Study:

  • To review recent literature on COVID-19 and its impact on gout patients.
  • To explore the relationship between gout pathophysiology and severe COVID-19.
  • To assess the pandemic's effect on gout management and patient quality of life.

Main Methods:

  • Systematic review of recently published articles.
  • Analysis of clinical trial data on gout medications in COVID-19 treatment.
  • Synthesis of findings on patient-reported outcomes and healthcare access.

Main Results:

  • Gout patients are at increased risk for adverse COVID-19 outcomes.
  • Gout medications like colchicine and IL-1 inhibitors show therapeutic potential for COVID-19.
  • The pandemic has led to difficulties in gout disease control, medication access, and reduced quality of life for patients.

Conclusions:

  • COVID-19 poses significant challenges for individuals with gout.
  • Further research is needed to establish clear management guidelines for gout during pandemics.
  • Understanding the interplay between gout and COVID-19 is crucial for patient care and treatment strategies.
Abstract

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