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Subacute thyroiditis post-Pfizer-BioNTech mRNA vaccination for COVID-19
Farooq Khan1, Mary Jane Brassill1
1Department of Endocrinology, Tipperary University Hospital, Clonmel, Co. Tipperary, Ireland.
Endocrinology, Diabetes & Metabolism Case Reports
|December 15, 2021
Summary
Emerging evidence suggests a link between COVID-19 vaccination and subacute thyroiditis. This condition, often presenting with hyperthyroidism or neck pain, is typically self-limiting and may be triggered by the autoimmune/inflammatory syndrome induced by adjuvants.
Area of Science:
- Endocrinology
- Immunology
- Vaccinology
Background:
- Subacute thyroiditis is an inflammatory condition of the thyroid gland.
- An association between COVID-19 vaccination and subacute thyroiditis is emerging.
- The autoimmune/inflammatory syndrome induced by adjuvants (AIIS) is a potential mechanism for post-vaccination autoimmune conditions.
Purpose of the Study:
- To report a case of subacute thyroiditis following COVID-19 vaccination.
- To discuss the potential role of AIIS in vaccine-associated subacute thyroiditis.
- To emphasize the importance of considering subacute thyroiditis in patients with relevant symptoms post-vaccination.
Main Methods:
- Case report of a 42-year-old female healthcare worker.
- Clinical presentation and course of subacute thyroiditis.
- Review of potential pathomechanisms, including AIIS.
Main Results:
- The patient developed subacute thyroiditis 4 days after her second dose of the Pfizer-BioNTech vaccine.
- Her condition followed a classical pattern of thyroiditis.
- Euthyroidism was spontaneously achieved at 6 months post-presentation.
Conclusions:
- Subacute thyroiditis is a potential adverse effect of COVID-19 vaccination.
- AIIS may contribute to vaccine-associated subacute thyroiditis.
- Recognition of subacute thyroiditis is crucial for appropriate patient management, as specific thyroid treatments are often unnecessary.
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