Related Experiment Video

Updated: Oct 10, 2025

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

3.9K

Assessment of Left Ventricular Function and Mitral Regurgitation Severity Early After Percutaneous Device Closure of

Mohammad Sahebjam1, Neda Toofaninejad1, Ali Ajam2,3

  • 1From the Department of Echocardiography, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Critical Pathways in Cardiology
|December 15, 2021
PubMed

Insights

Percutaneous closure of atrial septal defect (ASD) does not immediately alter left ventricular (LV) systolic function but increases LV end-diastolic diameter and mitral inflow velocity. The procedure effectively reduces right ventricular pressure without worsening mitral regurgitation early on.

Area of Science:

  • Cardiology
  • Echocardiography
  • Congenital Heart Disease

Background:

  • Atrial septal defect (ASD) is a common congenital heart disease in adults.
  • ASD closure normalizes right heart volumes but has variable effects on left ventricular (LV) function and mitral regurgitation (MR).

Purpose of the Study:

  • To evaluate the immediate impact of percutaneous ASD closure on LV function and MR severity.
  • To assess early changes in LV dimensions and diastolic function post-procedure.

Main Methods:

  • Prospective study of 32 patients with ASD secundum undergoing percutaneous device closure.
  • Transthoracic and transesophageal echocardiography performed pre-procedure and 24 hours post-procedure.
  • Comparison of LV parameters, including LVEDD, LVESD, LVEF, and MR severity, before and after closure.

Main Results:

  • LV end-diastolic diameter (LVEDD) significantly increased post-closure (P < 0.001).
  • LV ejection fraction (LVEF) remained unchanged; LV end-systolic diameter (LVESD) showed insignificant increase (P = 0.063).
  • Right ventricular systolic pressure decreased significantly (12.4%, P < 0.001), and mitral E/E' increased (9.7%, P = 0.010); MR severity change was insignificant (P = 0.157).

Conclusions:

  • Percutaneous ASD closure does not acutely impair LV systolic function.
  • Immediate increases in LVEDD and E/E' are observed due to altered diastolic filling patterns.
  • The procedure positively impacts right ventricular pressure and does not worsen MR early after closure.
Abstract

More Related Videos

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.0K
Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

21.8K

Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
43
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
78
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
75
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
60
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
47
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
80