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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

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Corneal Graft Rejection After Inactivated SARS-CoV-2 Vaccine: Case Report.

Mariana Fernandez Simão¹, Sérgio Kwitko²

¹Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; and.

|December 15, 2021

Summary

This summary is machine-generated.

Endothelial corneal allograft rejection occurred 24 hours after an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. This case highlights a potential complication following vaccination.

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Area of Science:

Ophthalmology
Vaccinology
Immunology

Background:

Corneal transplantation is a common procedure to restore vision.
Endothelial corneal allograft rejection is a known complication.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been widely administered globally.

Observation:

A 63-year-old female patient with a history of penetrating keratoplasty and laser in situ keratomileusis (LASIK) presented with symptoms of corneal graft rejection.
The rejection occurred 24 hours post-vaccination with CoronaVac, an inactivated SARS-CoV-2 vaccine.
Clinical examination revealed corneal edema and interface fluid accumulation, characteristic of LASIK interface fluid accumulation.

Findings:

This case report details the first association between an inactivated SARS-CoV-2 vaccine and endothelial corneal allograft rejection.
The presentation included atypical signs of LASIK interface fluid accumulation.
The patient's condition partially resolved with topical corticosteroids and polydimethylsiloxane treatment.

Implications:

Ophthalmologists should consider corneal allograft rejection as a potential complication after SARS-CoV-2 vaccination, particularly with inactivated vaccines.
Awareness of this association is crucial for timely diagnosis and management of post-vaccination ocular complications.
Further research is warranted to understand the immunological mechanisms linking SARS-CoV-2 vaccination to corneal allograft rejection.