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Stromal keratitis with anterior membrane dystrophy.

P A Jaros, V P deLuise

    Annals of Ophthalmology
    |October 1, 1986
    PubMed
    Summary

    Recurrent corneal erosions associated with anterior basement membrane dystrophy can lead to stromal keratitis. This condition presents as anterior stromal infiltrates without identifiable organisms.

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    Area of Science:

    • Ophthalmology
    • Corneal Diseases
    • Microbiology

    Background:

    • Recurrent corneal erosion syndrome (RCES) is a chronic condition affecting the cornea's surface.
    • Anterior basement membrane dystrophy (ABMD) is a common epithelial abnormality that can predispose to RCES.
    • Stromal keratitis is an inflammation of the corneal stroma, potentially leading to vision loss.

    Observation:

    • A 55-year-old woman presented with anterior stromal nummular infiltrates.
    • The patient had a history of recurrent corneal erosion syndrome and anterior basement membrane dystrophy.
    • Microscopic examination (Gram and Giemsa stains) and microbial cultures were negative for organisms.

    Findings:

    • The development of anterior stromal nummular infiltrates in this patient was attributed to RCES with ABMD.
    • Despite negative microbiological workup, the clinical presentation suggested an inflammatory stromal process.
    • Stromal keratitis is a potential complication of RCES, particularly when associated with ABMD.

    Implications:

    • This case highlights the importance of considering stromal keratitis in patients with RCES and ABMD, even with a negative microbiological workup.
    • Early recognition and management of stromal keratitis are crucial to prevent long-term visual impairment.
    • Further research may elucidate the specific mechanisms leading to sterile stromal inflammation in this context.

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