Hand-mirror-cell variant of B-cell lymphoma with hypercalcemia

The first (to my knowledge) case of confirmed hand-mirror cell (HMC) non-Hodgkin's lymphoma is described in a 56-year-old white woman. Surface-marker analysis indicated that the cells were B cells with surface IgM (lambda). The HMC phenomenon was considered to be real since it was seen on both Wright-Giemsa and supravital stains. In addition, this patient had uncontrollable hypercalcemia and unusual bone-scan findings. The significance of HMC and hypercalcemia in non-Hodgkin's lymphoma is discussed.