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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Source And Potency Of Stem Cells01:27

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Updated: Oct 10, 2025

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
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Why stem/progenitor cells lose their regenerative potential.

Angela Picerno1, Alessandra Stasi1, Rossana Franzin1

  • 1Department of Emergency and Organ Transplantation, University of Bari "Aldo Moro", Bari 70124, Italy.

World Journal of Stem Cells
|December 15, 2021
PubMed
Summary
This summary is machine-generated.

Adult stem cells (tissue stem cells) decline with age, impairing tissue repair and regeneration. Understanding stem cell aging and exploring rejuvenation strategies are crucial for treating age-related diseases.

Keywords:
AgingAging environmentAging-associated disordersEpigenetic changesRejuvenationSelf-renewalStem cells

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Area of Science:

  • Gerontology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Adult stem cells are vital for tissue repair and homeostasis through self-renewal and differentiation.
  • Stem cell aging leads to impaired regenerative capacity and contributes to age-associated disorders.
  • Cell-intrinsic damage and microenvironmental changes drive stem cell aging.

Purpose of the Study:

  • To review current knowledge on adult stem cell aging mechanisms.
  • To identify aging-related changes in stem cell number, function, and phenotype.
  • To explore potential stem cell rejuvenation strategies for therapeutic applications.

Main Methods:

  • Literature review of physiological and pathological aging in adult stem cells.
  • Analysis of molecular mechanisms underlying stem cell aging.
  • Examination of cell rejuvenation and regenerative medicine approaches.

Main Results:

  • Stem cell aging is characterized by reduced renewal ability and impaired differentiation capacity.
  • Epigenomic alterations and microenvironmental factors contribute to stem cell dysfunction.
  • Stem cell rejuvenation holds promise for reversing aging phenotypes.

Conclusions:

  • Stem cell aging significantly impacts tissue homeostasis and is linked to age-related diseases.
  • Targeting stem cell aging through rejuvenation may offer novel therapeutic avenues.
  • Advancements in stem cell therapies, including induced pluripotent stem cells, could treat age-related conditions.