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Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein Networks02:26

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
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Protein-protein interactions: Methods, databases, and applications in virus-host study.

Qurat Ul Ain Farooq1, Zeeshan Shaukat2, Sara Aiman1

  • 1Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing 100124, China.

World Journal of Virology
|December 15, 2021
PubMed
Summary

Protein-protein interactions (PPIs) are crucial for cellular functions and understanding virus-host relationships. This review covers PPI methods, databases, and their application in studying viral infections and host interactions.

Keywords:
Disease pathwaysExperimental and computational methodsProtein-protein interaction applicationsProtein-protein interaction databasesProtein-protein interaction networksProtein-protein interactions

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Area of Science:

  • Molecular Biology
  • Virology
  • Bioinformatics

Background:

  • Proteins control nearly all cellular processes, including gene expression, catalysis, and signaling.
  • Protein-protein interactions (PPIs) are fundamental to complex biological functions and disease mechanisms.
  • Virus-host interactions often initiate through protein-protein contacts.

Purpose of the Study:

  • To review the importance of PPI networks in understanding virus-host relationships.
  • To discuss experimental and computational methods for identifying PPIs.
  • To highlight databases and applications related to virus-host PPIs.

Main Methods:

  • Experimental techniques for PPI detection (e.g., yeast two-hybrid, co-immunoprecipitation).
  • Computational approaches for predicting and analyzing PPIs.
  • Database curation and integration of virus-host interaction data.

Main Results:

  • PPI networks are essential for deciphering molecular mechanisms of viral infections.
  • Databases provide valuable resources for studying virus-host PPIs.
  • Analysis of PPIs aids in identifying disease targets and understanding viral pathogenesis.

Conclusions:

  • PPIs and their networks are critical for understanding virus-host dynamics.
  • Comprehensive databases and analytical methods facilitate research in this area.
  • Further exploration of PPIs holds potential for therapeutic strategies against viral diseases.