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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Related Experiment Video

Updated: Oct 10, 2025

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
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ImmunoStart: preparing patients for immunosuppression.

Charlotte Martin1, Vinciane Muls2, Céline Brasseur3

  • 1Department of Infectious Diseases.

Rheumatology Advances in Practice
|December 15, 2021
PubMed
Summary
This summary is machine-generated.

The ImmunoStart consultation effectively manages infections in immune-mediated inflammatory disease (IMID) patients. It systematically addresses vaccination needs, latent tuberculosis, and immunomodulating treatment risks.

Keywords:
immune-mediated inflammatory diseaseimmunosuppressionlatentpreventionscreeningvaccination

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Rheumatology

Background:

  • Patients with immune-mediated inflammatory diseases (IMID) face heightened infection risks.
  • Proactive management of infectious risks is crucial for IMID patient care.

Purpose of the Study:

  • To introduce the ImmunoStart preventive consultation concept.
  • To report initial findings on ImmunoStart's implementation in IMID patient care pathways.

Main Methods:

  • Infectious risk assessment including vaccination history, tuberculosis exposure, and diagnostics (blood tests, X-ray, Mantoux).
  • The ImmunoStart consultation involved discussing vaccination schedules, treatments, and risk factors.

Main Results:

  • 437 IMID patients attended ImmunoStart consultations (Oct 2016-Feb 2020).
  • 96% required vaccinations (mean 3.3/patient); 10% needed live attenuated vaccines, necessitating immunosuppressive drug adjustment.
  • 21% were treated for latent tuberculosis infection.

Conclusions:

  • ImmunoStart offers a centralized, systematic approach for managing IMID patients' vaccination and latent disease treatment needs.
  • The consultation provides essential advice on immunomodulating treatments to mitigate infection risks.