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Case report of heart transplantation for giant cell myocarditis in a patient with common variable immunodeficiency

Thomas A Franzon1, Anna Kovalszki2, Raja Rabah3

  • 1Cardiovascular Medicine, University of Michigan, 2381 CVC SPC 5853, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5853, USA.

European Heart Journal. Case Reports
|December 15, 2021
PubMed

Insights

Heart transplantation for patients with common variable immunodeficiency (CVID) is feasible. A CVID patient with giant cell myocarditis (GCM) successfully received a heart transplant and remained complication-free for two years.

Area of Science:

  • Immunology
  • Cardiology
  • Transplantation

Background:

  • Solid-organ transplantation in common variable immunodeficiency (CVID) patients is controversial due to infection risks and potential recurrence of non-infectious complications.
  • Limited data exist on solid-organ transplantation outcomes in CVID patients, especially for heart transplantation.

Observation:

  • A 32-year-old female with CVID presented with severe heart failure due to giant cell myocarditis (GCM).
  • She underwent orthotopic heart transplantation due to progressive cardiogenic shock despite medical management.

Findings:

  • The patient experienced an uncomplicated heart transplant and remained free of major infectious complications for two years post-transplant.
  • Graft function remained normal, with no recurrence of GCM observed during the follow-up period.

Implications:

  • This case suggests that CVID should not be an absolute contraindication for heart transplantation.
  • Successful heart transplantation in CVID patients with GCM is possible, challenging previous concerns about transplant candidacy.
Abstract

Keywords:
Acute heart failureCardiomyopathyCase reportCommon variable immunodeficiencyHeart transplant

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