Identification of vaccine candidate proteins in Ureaplasma urealyticum causing infertility
Shilpa Jeevappa Shiragannavar1, Shivakumar B Madagi1
1Department of Studies and Research in Bioinformatics and Biotechnology, Karnataka State Akkamahadevi Women's University, Vijayapura, Karnataka, India.
Background:
Ureaplasma urealyticum has gained resistance to number of antibiotics and has been of the greatest concerns nowadays. The treatment options remain extremely low due to the increased levels of intrinsic resistance gained by the pathogen.
Aim:
The present study focuses on designing a peptide-based vaccine as there is no vaccine available for the pathogen.
Materials And Methods:
All the protein sequences of pathogen were collected and examined using various in silico methods to identify the most immunogenic proteins. The study identifies the proteins which are antigenic in nature which induce the immune response, which lends to quick response of immune system on reinfection. The study describes peptide-based vaccine against U. urealyticum using molecular docking and molecular dynamics simulation approach.
Results:
The study identifies novel putative vaccine candidate proteins that are antigenic, membrane bound and non-allergenic.
Conclusion:
The results of the study imply that the vaccine candidate proteins identified may bring about vigorous enduring defensive immunity against U. urealyticum.
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