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Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
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Epidemiology of Pemphigus
Khalaf Kridin1,2, Enno Schmidt1,3
1Lűbeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
JID Innovations : Skin Science From Molecules to Population Health
|December 15, 2021
Summary
Pemphigus, a group of autoimmune blistering diseases, shows varied epidemiology and newly identified genetic factors. This research also explores comorbidities and the impact of COVID-19 on affected patients.
Area of Science:
- Dermatology
- Immunology
- Epidemiology
Background:
- Pemphigus encompasses diverse autoimmune bullous diseases, including pemphigus vulgaris (PV) and pemphigus foliaceus.
- Epidemiological data on pemphigus frequency across populations are expanding.
- Recent research identified non-HLA genes associated with PV and noted comorbidities like psoriasis and hematological malignancies.
Purpose of the Study:
- To summarize current epidemiological knowledge of pemphigus.
- To discuss comorbidities associated with pemphigus.
- To review the impact of COVID-19 on pemphigus patients and suggest future research directions.
Main Methods:
- Literature review and data synthesis on pemphigus epidemiology.
- Analysis of comorbidities in pemphigus patients.
- Discussion of preliminary data on COVID-19 impact.
Main Results:
- Pemphigus epidemiology is highly variable globally.
- Non-HLA gene associations with PV have been established.
- Comorbidities such as autoimmune diseases, malignancies, and psoriasis are frequent in pemphigus patients.
Conclusions:
- Pemphigus patient populations are diverse and require comprehensive management.
- Further epidemiological studies are needed to understand pemphigus variations.
- The impact of COVID-19 on this patient group warrants continued investigation.
Keywords:
ACE, angiotensin-converting enzymeAIBD, autoimmune bullous diseaseCAAR, chimeric autoantibody receptorCI, confidence intervalDSG, desmogleinEADV, European Academy of Dermatology and VenereologyEC, extracellularEMA, European Medicines AgencyFS, fogo selvageHR, hazard ratioICD, International Classification of DiseasesPF, pemphigus foliaceusPNP, paraneoplastic pemphigusPV, pemphigus vulgarisSMR, standardized mortality ratioMore Related Videos
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