Comparison of C-reactive protein and C-reactive protein-to-albumin ratio in predicting mortality among geriatric coronavirus disease 2019 patients
Related Experiment Video
Updated: Oct 10, 2025
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Rohat Ak1, Fatih Doğanay2, Erdal Yilmaz1
1Kartal Dr. Lütfi Kırdar City Hospital, Department of Emergency Medicine - Istanbul, Turkey.
Insights
C-reactive protein and the C-reactive protein-to-albumin ratio effectively predict mortality in elderly COVID-19 patients. Both biomarkers demonstrated success in identifying high-risk individuals in emergency department settings.
Area of Science:
- Geriatric Medicine
- Infectious Diseases
- Biomarker Research
Background:
- Elderly individuals are highly susceptible to severe COVID-19 outcomes.
- Accurate prediction of mortality risk is crucial for managing geriatric COVID-19 patients.
Purpose of the Study:
- To evaluate and compare the performance of C-reactive protein (CRP) and the CRP-to-albumin ratio (CRP/Alb) in predicting mortality among geriatric patients presenting to the emergency department with COVID-19.
Main Methods:
- Retrospective analysis of electronic health records for COVID-19 patients aged 65 and above who visited the emergency department.
- Utilized Area Under the Receiver Operating Characteristic Curve (AUC) to assess the discriminatory power of CRP and CRP/Alb for mortality prediction.
Main Results:
- Both CRP (AUC=0.635) and CRP/Alb (AUC=0.645) showed significant predictive value for mortality in geriatric COVID-19 patients.
- Sensitivity and specificity values were 71.01% and 52.34% for CRP, and 75.74% and 47.66% for CRP/Alb, respectively.
- No statistically significant difference was observed between the predictive performances of CRP and CRP/Alb.
Conclusions:
- C-reactive protein and C-reactive protein-to-albumin ratio are valuable tools for predicting mortality in elderly COVID-19 patients.
- These biomarkers can aid in risk stratification and clinical decision-making for vulnerable geriatric populations.
Objective:
The aim of this study was to evaluate and compare C-reactive protein and C-reactive protein-to-albumin ratio performances in predicting mortality of geriatric patients who visited the emergency department.
Methods:
The data of patients with COVID-19 and aged 65 years and above, who visited emergency department during the study period, were retrospectively analyzed. The data were obtained from an electronic-based hospital information system. The area under the receiver operating characteristic curve and the area under the curve were used to assess each cutoff value discriminatory for predicting mortality.
Results:
The mean age of the population included in this study was 76 (71-82) years, while 52.7% were males. The sensitivity, specificity, and area under the curve values for C-reactive protein in terms of mortality were calculated as 71.01, 52.34, and 0.635%, respectively, while the sensitivity, specificity, and area under the curve values for C-reactive protein-to-albumin ratio were calculated as 75.74, 47.66, and 0.645%, respectively (p<0.001). In the pairwise comparison for the receiver operating characteristic curves of C-reactive protein and C-reactive protein-to-albumin ratio, no statistically significant difference was found.
Conclusions:
Geriatric patients are the "most vulnerable" patient group against the COVID-19. In this study, both C-reactive protein and C-reactive protein-to-albumin ratio were found to be successful in predicting mortality for geriatric COVID-19 patients.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Pneumonia III: Complications and Assessment
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
01:12Relative Risk