[NADPH-dependent oxidation in endoplasmic reticulum of rat liver after valexon administration]

Changes of different type are detected in components of NADPH-dependent oxidation. The changes begin in different periods (1, 5, 15 days) after administration of valexon to the animals. In the first day the hydroxylase activity is inhibited against a background of the uridine diphosphate glucuronyl transferase activity increase and intensification of ascorbic acid excretion with urine. Five days after the uridine diphosphate glucuronyl transferase activity becomes normal, the ascorbic acid excretion remains intensified and the demethylase and hydroxylase activities increase. Fifteen days later the hydroxylase activity becomes normal, but the demthylase activity and intensity of ascorbic acid excretion are still increased.