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Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Drug Dosing: Obese Patients01:21

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Related Experiment Video

Updated: Oct 10, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
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Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

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Precision Medicine and Obesity.

Daniel Sacoto1, Maria Daniela Hurtado2,3, Andres Acosta4,5

  • 1Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Handbook of Experimental Pharmacology
|December 15, 2021
PubMed
Summary

Precision medicine offers new hope for tackling obesity, a complex disease. This review explores current initiatives using -omics and physiologic traits to personalize obesity treatment for better outcomes.

Keywords:
ObesityPhenotypePrecision medicine

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Area of Science:

  • Obesity research
  • Precision medicine
  • Metabolic disease

Background:

  • Obesity is a complex, multifactorial chronic disease with increasing prevalence and significant economic impact.
  • Current interventions face challenges in achieving sustained weight loss due to the poorly understood, heterogeneous pathophysiology of obesity.
  • Technological advancements are enabling precision medicine approaches to address obesity more effectively.

Purpose of the Study:

  • To review current precision medicine initiatives aimed at improving obesity treatment outcomes.
  • To provide a perspective on the application of -omics technologies and physiologic traits in personalized obesity care.
  • To highlight the potential clinical impact of different precision medicine strategies for obesity.

Main Methods:

  • Review of current literature on precision medicine in obesity.
  • Analysis of initiatives utilizing -omics technologies (genomics, proteomics, etc.).
  • Evaluation of approaches focusing on quantitative or qualitative physiologic traits.

Main Results:

  • Several precision medicine initiatives for obesity have been proposed, primarily leveraging -omics data.
  • While -omics data generate hypotheses, clinical applicability for obesity treatment is still under investigation.
  • Other initiatives identify specific physiologic traits with potential for more immediate clinical impact in obesity management.

Conclusions:

  • Precision medicine holds promise for advancing obesity treatment.
  • -Omics technologies offer insights but require further validation for clinical practice.
  • Targeting specific physiologic traits may provide more immediate clinical benefits for personalized obesity care.