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Updated: Oct 10, 2025

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
Published on: February 6, 2018
A Case of AB Para-Bombay Phenotype with Weak A Antigen Expression
Background:
The Para-Bombay phenotype is characterized by H antigen partially or totally deficient on red blood cells and the presence of ABH substances in body fluids.
Methods:
A patient with discrepant results in forward and reverse ABO phenotyping was further investigated by serological and molecular methods.
Results:
Ortho gel and tube results showed weak A antigen expression and weak antibody reacting with A and B cells. Absorption-elution assay detected B antigen, and saliva test confirmed substances H were present. The patient was confirmed as A102B101 and Le(a+b+) phenotype.
Conclusions:
These findings suggest that the case is AB Para-Bombay Phenotype (secretor).
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