Related Experiment Video
Updated: Oct 10, 2025

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
Published on: February 10, 2023
Rearrangements in Scholl Reaction
Nagaraju Ponugoti1, Venkatakrishnan Parthasarathy1
1Department of Chemistry, Indian Institute of Technology Madras, 600 036, Chennai, Tamil Nadu, India.
Abstract:
Rearrangements in Scholl reaction are mostly serendipitous. The design of molecular precursors is what seems to guide the course of rearrangement. This review consolidates different classes of precursors used in Scholl reaction and their accompanying rearrangements that include aryl migration, migration followed by cyclization and skeletal rearrangements involving ring expansion, ring contraction and both, under the reaction conditions. The attempt in collating heretofore-reported examples in this review is to guide designing appropriate precursors to predictably achieve complex molecular structures or nanographenes or defect-nanographenes via rearrangement.
More Related Videos
11:44Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
07:36Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Related Concept Videos
[3,3] Sigmatropic Rearrangement of Allyl Vinyl Ethers: Claisen Rearrangement
SN2 Reaction: Stereochemistry
If the substrate is an achiral molecule at the α-carbon, the inversion of configuration is not...
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement
Preparation of Alcohols via Substitution Reactions
Alcohols can be synthesized from alkyl halides via nucleophilic substitution reactions. The highly polar carbon-halogen bond in the substrate makes halide a good leaving group. The hydroxide ion or water can act as a nucleophile to take the place of halide and form an alcohol. The substitution reactions occur via two different reaction pathways, SN1 or SN2, depending on the nature of carbon attached to the halide.
Primary alcohols are synthesized from primary alkyl halides, and the...
Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between...