Rearrangements in Scholl Reaction

Area of Science:

• Organic Chemistry
• Synthetic Chemistry

Background:

• Scholl reactions often yield unpredictable rearrangements.
• Molecular precursor design is key to controlling these reactions.

Purpose of the Study:

• To review precursor classes and their rearrangements in the Scholl reaction.
• To guide the design of precursors for predictable synthesis of complex molecules.

Main Methods:

• Consolidation of reported examples of Scholl reaction precursors.
• Categorization of rearrangements including aryl migration, cyclization, and skeletal changes.

Main Results:

• Identified diverse precursor classes influencing Scholl reaction outcomes.
• Documented rearrangements such as aryl migration, ring expansion, and contraction.
• Demonstrated the link between precursor structure and rearrangement pathways.

Conclusions:

• Precursor design is crucial for predictable Scholl reaction outcomes.
• This review provides a framework for synthesizing complex molecular architectures, nanographenes, and defect-nanographenes.