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Related Concept Videos

The Extracellular Matrix01:29

The Extracellular Matrix

9.8K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
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Extracellular Matrix01:26

Extracellular Matrix

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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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Cell Motility through Blebbing01:16

Cell Motility through Blebbing

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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
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Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

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Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
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Updated: Oct 10, 2025

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
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A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

Published on: January 4, 2017

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Cell-extracellular matrix dynamics.

Andrew D Doyle1, Shayan S Nazari1, Kenneth M Yamada1

  • 1Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20892, United States of America.

Physical Biology
|December 15, 2021
PubMed
Summary
This summary is machine-generated.

Cell-extracellular matrix interactions, mediated by integrins, are crucial for cell functions and adaptations. Dysregulation of these cell-ECM interactions drives cancer invasion and metastasis.

Keywords:
cell migrationdynamicsextracellular matrixfocal adhesions

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Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
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Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

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Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
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Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
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Area of Science:

  • Cell Biology
  • Biochemistry
  • Cancer Research

Background:

  • Cell-environment interactions are dynamic signaling hubs regulating cellular processes.
  • Integrin receptors binding to extracellular matrix (ECM) proteins mediate most cell-ECM contacts.
  • These interactions provide cells with critical environmental cues.

Purpose of the Study:

  • To review recent advances in understanding cell-ECM interaction mechanisms and regulation.
  • To focus on the role of cell-ECM interactions in cell migration.
  • To explore the link between altered cell-ECM interactions and cancer metastasis.

Main Methods:

  • Literature review of recent advances and hypotheses.
  • Analysis of mechanisms from molecular to tissue levels.
  • Focus on cell migration and cancer invasion.

Main Results:

  • Cell-ECM interactions are complex, involving both extracellular and intracellular components.
  • Integrins are key mediators of cell adhesion to ECM proteins like collagen and fibronectin.
  • Altered regulation of cell-ECM interactions is fundamental to cancer cell invasion and metastasis.

Conclusions:

  • Understanding cell-ECM interactions is vital for comprehending normal cellular functions and disease states.
  • Recent advances provide new insights into the regulation of these interactions.
  • Targeting cell-ECM interactions may offer therapeutic strategies for cancer metastasis.