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Updated: Oct 10, 2025

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
Published on: September 8, 2023
The omicron variant of SARS-CoV-2: Understanding the known and living with unknowns
Nicholas E Ingraham1, David H Ingbar1
1Pulmonary, Allergy, Critical Care, and Sleep Medicine Division, Department of Medicine, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Abstract:
The recently discovered Omicron variant of SARS-CoV-2 has rapidly burst into the public and scientific eye, being detected in more than 26 countries around the world. Given its more than 50 mutations, there is widespread concern about its public health impact, leading the World Health Organization to designate it a variant of concern. This Commentary provides a summary of current knowledge and unknowns about this viral variant as of December 2, 2021 and summarizes the key questions that need to be rapidly answered.
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