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Updated: Oct 10, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Waldenström macroglobulinemia.

K Baďurová, J Gregorová, M Vlachová

Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti

|December 16, 2021

Summary

This summary is machine-generated.

Waldenström macroglobulinemia (WM) is a slow-growing blood cancer. Understanding its genetic basis, like MYD88 mutations, is key for effective treatment with targeted therapies such as ibrutinib.

Keywords:

Mutation Prognosis Waldenström macroglobulinemia heart failure incidence microRNAs mikroRNA mutation

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Last Updated: Oct 10, 2025

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Published on: June 29, 2016

Area of Science:

Hematology
Oncology
Molecular Biology

Background:

Waldenström macroglobulinemia (WM) is a rare hematological malignancy characterized by lymphoplasmacytoid cell infiltration of the bone marrow.
Patients typically present with anemia, fatigue, and potential organ enlargement; hyperviscosity syndrome can occur due to IgM production.
The median age at diagnosis is 71, with the disease generally having an indolent course.

Purpose of the Study:

To provide a comprehensive overview of Waldenström macroglobulinemia.
To detail the diagnostic approaches, underlying molecular basis, and current treatment strategies for WM.

Main Methods:

Literature review and synthesis of existing knowledge on WM.
Analysis of diagnostic criteria and molecular markers.
Evaluation of therapeutic options, including targeted therapies.

Main Results:

MYD88 gene mutations are nearly universal in WM patients, while CXCR4 mutations occur in about one-third.
The presence of MYD88 and CXCR4 mutations influences treatment selection, particularly for Bruton's tyrosine kinase inhibitors like ibrutinib.
Therapy initiation is guided by the onset of clinical symptoms.

Conclusions:

Accurate diagnosis and molecular profiling, especially MYD88 and CXCR4 status, are crucial for personalized WM treatment.
Targeted therapies offer improved outcomes for WM patients, particularly those with specific genetic profiles.
Continued research into the molecular underpinnings of WM will further refine therapeutic strategies.