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Primary breast lymphoma - a case report.

W Rajabto, Y K Angkasa, A S Harahap

    Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti
    |December 16, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Primary breast lymphoma, a rare cancer, is most commonly diffuse large B-cell lymphoma (DLBCL). The R-CHOP chemotherapy regimen effectively treats this condition, leading to long-term remission.

    Keywords:
    Diffuse large B-cell lymphomaR-CHOP chemotherapyprimary breast lymphoma

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    Area of Science:

    • Oncology
    • Hematology
    • Medical Imaging

    Background:

    • Primary breast lymphoma is a rare malignancy, representing a small fraction of breast cancers and extra-nodal lymphomas.
    • Diffuse large B-cell lymphoma (DLBCL) is the predominant histological subtype of primary breast lymphoma.

    Observation:

    • A 47-year-old female with beta thalassemia presented with a symptomatic left breast mass, exhibiting redness and swelling.
    • Imaging revealed a large, hypermetabolic mass in the left breast with involvement of adjacent lymph nodes.
    • Histopathology confirmed a CD20-positive, non-germinal center B-cell-like subtype of DLBCL.

    Findings:

    • The patient received six cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy.
    • Treatment resulted in a complete remission of the primary breast lymphoma.
    • The patient tolerated the chemotherapy well and maintained long-term remission.

    Implications:

    • Systemic chemotherapy with R-CHOP is a viable and effective treatment strategy for primary breast diffuse large B-cell lymphoma.
    • This case highlights the successful management of a rare oncological presentation with standard-of-care chemotherapy.
    • Further research into rare breast malignancies can inform optimal treatment protocols.