Related Experiment Video
Updated: Oct 10, 2025
06:46
Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
Published on: July 25, 2025
398
Two-step versus 1-step subretinal injection to compare subretinal drug delivery: a randomised study protocol
Matthew P Simunovic1,2, Emily H Shao2, Perach Osaadon2
1Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia matthew.simunovic@sydney.edu.au.
BMJ Open
|December 16, 2021
Summary
This study compares two subretinal injection techniques for delivering medication to the eye. It quanties drug retention and evaluates surgical variables for improved ocular disease treatments.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Drug Delivery Systems
Background:
- Subretinal injections are crucial for emerging ocular disease treatments.
- Surgical variables and drug retention in subretinal injections are not well understood.
- Accurate drug delivery is essential for treatment efficacy.
Purpose of the Study:
- To quantify the proportion of subretinally injected medication retained after surgery.
- To compare the efficacy of two subretinal injection techniques: '1-step' versus '2-step'.
- To investigate surgical variables impacting drug delivery in ocular treatments.
Main Methods:
- A randomized controlled trial comparing '1-step' and '2-step' subretinal injection techniques.
- Utilizing sodium fluorescein as an optical tracer to quantify drug reflux.
- Administering alteplase for submacular hemorrhage, with bevacizumab and SF6 gas as vitreous substitutes.
Main Results:
- (Results not yet available as this outlines a trial protocol)
Conclusions:
- (Conclusions not yet available as this outlines a trial protocol)
