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Updated: Oct 10, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
A data-driven approach to measuring epidemiological susceptibility risk around the world
Alessandro Bitetto1, Paola Cerchiello2, Charilaos Mertzanis3
1Department of Economics and Management, University of Pavia, Pavia, 27100, Italy. alessandro.bitetto@unipv.it.
Abstract:
Epidemic outbreaks are extreme events that become more frequent and severe, associated with large social and real costs. It is therefore important to assess whether countries are prepared to manage epidemiological risks. We use a fully data-driven approach to measure epidemiological susceptibility risk at the country level using time-varying information. We apply both principal component analysis (PCA) and dynamic factor model (DFM) to deal with the presence of strong cross-section dependence in the data. We conduct extensive in-sample model evaluations of 168 countries covering 17 indicators for the 2010-2019 period. The results show that the robust PCA method accounts for about 90% of total variability, whilst the DFM accounts for about 76% of the total variability. Our index could therefore provide the basis for developing risk assessments of epidemiological risk contagion. It could be also used by organizations to assess likely real consequences of epidemics with useful managerial implications.
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