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The role of Ubiquitination in Apoptosis and Necroptosis

Jamie Z Roberts1, Nyree Crawford2, Daniel B Longley3

  • 1The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK. jroberts10@qub.ac.uk.

Cell Death and Differentiation
|December 16, 2021
PubMed

Insights

Ubiquitination regulates programmed cell death pathways like apoptosis and necroptosis. This review explores how ubiquitination controls these crucial cell death mechanisms, impacting tissue homeostasis and disease.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Immunology

Background:

  • Cell death pathways are essential for maintaining tissue homeostasis and eliminating damaged cells.
  • Apoptosis, a non-inflammatory cell death, has intrinsic and extrinsic branches.
  • Extrinsic apoptosis and necroptosis are regulated by tumor necrosis factor (TNF) receptor superfamily members.

Purpose of the Study:

  • To review the role of ubiquitination in regulating apoptotic signaling pathways.
  • To discuss the emerging importance of ubiquitination in necroptosis regulation.

Main Methods:

  • Literature review of research on ubiquitination and cell death.
  • Analysis of post-translational modifications in apoptosis and necroptosis.

Main Results:

  • Ubiquitination is a key post-translational modification controlling apoptosis.
  • Emerging evidence highlights ubiquitination's role in regulating necroptosis.

Conclusions:

  • Ubiquitination plays a critical role in the precise control of both apoptosis and necroptosis.
  • Understanding ubiquitination's role is vital for comprehending cell death regulation and its implications in disease.

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