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Related Experiment Video

Updated: Oct 9, 2025

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

Dasatinib-Induced Nephrotic Syndrome: A Case Report.

Ahmed ElShaer¹, Mazen Almasry¹, Maher Alawar²

¹Internal Medicine, Alfaisal University College of Medicine, Riyadh, SAU.

|December 16, 2021

Summary

Second-generation tyrosine kinase inhibitors (TKIs) like dasatinib can cause rare kidney problems in chronic myeloid leukemia (CML) patients. This case highlights nephrotic syndrome, which resolved after switching to nilotinib.

Area of Science:

Oncology
Nephrology
Pharmacology

Background:

Second-generation tyrosine kinase inhibitors (TKIs), including dasatinib and nilotinib, are crucial in treating chronic myeloid leukemia (CML).

Keywords:

adverse event case report proteinuria renal disease tyrosine kinase inhibitor

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Last Updated: Oct 9, 2025

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While generally safe, these TKIs are associated with adverse events like pulmonary hypertension and cardiovascular issues.

Renal complications are infrequently reported with TKI therapy.