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A multifunctional supramolecular hydrogel for infected wound healing
Tingting Ding1, Jiajia Qi1, Jingcheng Zou2
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, P. R. China. zhaohangahy@scu.edu.cn.
A new tannic acid and guanosine hydrogel offers excellent antibacterial and adhesive properties for wound healing. This innovative material degrades within three days and promotes faster wound repair in mice.
Area of Science:
- Biomaterials Science
- Wound Healing Research
- Regenerative Medicine
Background:
- Bacterial infections significantly impede wound healing.
- Existing wound dressings have limitations in antibacterial efficacy, adhesion, and degradation control.
- There is a need for advanced wound dressing materials with combined functionalities.
Purpose of the Study:
- To synthesize a novel supramolecular soft hydrogel for wound repair.
- To evaluate the antibacterial, adhesive, degradation, and antioxidant properties of the hydrogel.
- To assess the in vivo wound healing acceleration potential of the hydrogel.
Main Methods:
- One-pot synthesis of a guanosine-tannic acid (G-TA) hydrogel using dynamic borate esters.
- Evaluation of antibacterial activity against wound pathogens.
- Assessment of in vivo degradation profiles (within 3 days).
- In vitro cytocompatibility testing with L929 fibroblast cells.
Main Results:
- The G-TA hydrogel exhibited excellent antibacterial and adhesive properties.
- The hydrogel demonstrated rapid in vivo degradation within three days.
- Remarkable antioxidant capability, injectability, and in vitro stability were observed.
- The hydrogel significantly accelerated the healing of full-thickness skin wounds in mice.
Conclusions:
- The G-TA hydrogel is a promising biomaterial for advanced wound dressings.
- Its multifunctional properties, including antibacterial and pro-healing effects, support its application in wound repair.
- The simple synthesis and favorable degradation profile make it a viable candidate for clinical translation.
