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Trichosporon inkin fungemia case report: clinical and laboratory management

Franz Ag Santos1, Melyna C Leite-Andrade1, Maria Ara Vasconcelos2

  • 1Federal University of Pernambuco, Recife, Pernambuco, 50670-901, Brazil.

Future Microbiology
|December 16, 2021
PubMed

Insights

This study reports a rare case of Trichosporon inkin fungemia in a patient without hematological diseases. Delayed diagnosis and treatment contributed to the fatal outcome, highlighting the need for vigilance against unusual fungal infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Clinical Case Study

Background:

  • Trichosporon species are opportunistic pathogens, frequently causing fungemia in immunocompromised individuals, particularly those with onco-hematological diseases.
  • Trichosporon asahii is the most common species implicated in fungemia, while infections by other Trichosporon species are less frequently reported.

Observation:

  • This paper details a rare case of Trichosporon inkin fungemia in a 39-year-old female patient presenting with intestinal obstruction.
  • The patient had no underlying malignant hematological diseases, a demographic typically associated with Trichosporon fungemia.

Findings:

  • Late mycological diagnosis hindered timely intervention.
  • Ineffective management of the patient's pre-existing intestinal obstruction and delayed initiation of antifungal therapy were critical factors.
  • These delays ultimately contributed to the patient's mortality.

Implications:

  • This case underscores the importance of considering rare fungal pathogens like Trichosporon inkin in the differential diagnosis of fungemia, even in non-immunocompromised patients.
  • It highlights the critical role of prompt diagnosis and management of underlying conditions in improving outcomes for invasive fungal infections.
  • The findings emphasize the need for broader diagnostic awareness and timely antifungal treatment protocols for invasive Trichosporon infections.
Keywords:
Invasive trichosporonosisT. inkinTrichosporon infectionantifungal therapydiagnosis

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