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Updated: Oct 9, 2025

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
Published on: March 1, 2019
[SARS-CoV-2 damages male fertility: How and why]
Bang Sun1, Xue-Yan Wu1, Min Nie1
1Key Laboratory of Endocrinology of National Health Commission / Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Abstract:
The male reproductive system has a structural basis for being invaded by the SARS-CoV-2 virus. Existing evidence shows that SARS-CoV-2 can cause substantial damage to testicular tissues, pituitary-testicular axis hormone homeostasis, and production and quality of sperm in male patients. Local inflammation of the testis, cytokine storm and fever are considered to be the potential pathogenic factors for testis injury. COVID-19, as a rapidly spreading disease, requires close attention for its impact on the male reproductive system.
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