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Updated: Oct 9, 2025

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
Published on: May 11, 2017
[Correlation of single nucleotide polymorphisms of the osteopontin gene with astheozoospermia]
Yu-Xia Wei1, Yu-Lan Lu1, Bi-Yun Liao1
1Center of Reproductive Medicine, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China.
Objective:
To investigate the correlation of the single nucleotide polymorphisms (SNP) rs1126772, rs117291487, rs11730582, rs142608941 and rs6813526 of the osteopontin (OPN) gene with the risk of asthenozoospermia (AZS).
Methods:
We included 135 AZS patients in the AZS group and another 239 fertile men as normal controls. Using the SNaPshot technique, we genotyped the rs1126772, rs117291487, rs11730582, rs142608941 and rs6813526 polymorphisms of the OPN gene in all the subjects and analyzed the correlation of the five SNPs with AZS.
Results:
The GA genotype and A allele of the OPN gene rs1126772 were found to be correlated with the risk of AZS (GA vs AA: OR = 0.55, 95% CI: 0.35-0.86, P = 0.009; A vs G: OR = 0.64, 95% CI: 0.46-0.89, P = 0.007), and so was the CT genotype and T allele at the RS11730582 locus (CT vs TT: OR = 0.526, 95% CI: 0.34-0.82, P = 0.009; T vs C: OR = 0.60, 95% CI: 0.44-0.83, P = 0.002). Haplotype analysis showed that the AATCT haplotype decreased the risk of AZS (AATCT: OR = 0.61, 95% CI: 0.42-0.88, P = 0.008) .
Conclusions:
The polymorphisms of the OPN gene RS1126772 and RS11730582 may reduce the risk of AZS.
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