[Effects of exercise intervention on mitochondrial-derived peptide MOTS-c in the germ cells of obese men]
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Updated: Oct 9, 2025
Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
Published on: October 4, 2024
Yi-Ran Li1, Mei-Si Kang1, Xue-Jie Yi1
1School of Sports and Human Sciences, Shenyang Sport College, Shenyang, Liaoning 110102, China.
Abstract:
Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a newly discovered mitochondrial-derived peptide with the main functions of promoting glucose metabolism and reducing adipose tissue. MOTS-c was found to be a substance that can mimic the motor effect and improve the motor ability. It is sex-related and the circulating MOTS-c level is decreased in obese males. Obesity can cause male reproductive dysfunction, while exercise can improve obesity-induced reduction of male reproductive function. This article discusses the effect of exercise intervention on the mitochondrial-derived peptide MOTS-c in the germ cells of obese men.
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