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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Updated: Oct 9, 2025

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

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[Prostate cancer stem cells: Current understanding].

Xing Zhang1,2, Zi-Yang Han1, Yun Chen1

  • 1Department of Andrology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China.

Zhonghua Nan Ke Xue = National Journal of Andrology
|December 16, 2021
PubMed
Summary
This summary is machine-generated.

Prostate cancer may originate from stem cells, which drive tumor growth and resistance. Targeting these prostate cancer stem cells offers a promising therapeutic strategy for this common male malignancy.

Keywords:
prostate cancercancer stem cellmolecular markerpathogenesisstem cell

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Area of Science:

  • Oncology
  • Stem Cell Biology
  • Urology

Background:

  • Prostate cancer is a leading cause of cancer-related mortality in men.
  • Current understanding of prostate cancer cannot fully explain its heterogeneity, metastasis, drug resistance, and recurrence.
  • Prostate stem cells are crucial for prostate tissue regeneration and homeostasis.

Purpose of the Study:

  • To review the origin, identification, and molecular markers of prostate cancer stem cells (PCSCs).
  • To discuss the role of PCSCs in prostate cancer pathogenesis and therapeutic resistance.
  • To explore potential clinical applications of targeting PCSCs for novel treatment strategies.

Main Methods:

  • Literature review focusing on prostate stem cells and cancer stem cell hypothesis.
  • Analysis of studies on PCSC identification, markers, and functional characteristics.
  • Synthesis of information regarding therapeutic strategies targeting PCSCs.

Main Results:

  • Prostate cancer stem cells exhibit enhanced self-renewal, proliferation, and clonogenicity.
  • PCSCs are implicated in tumor initiation, progression, metastasis, and recurrence.
  • PCSCs demonstrate increased resistance to conventional cancer therapies.

Conclusions:

  • Prostate cancer may be viewed as a stem cell-driven disease.
  • Targeting PCSCs holds significant potential for developing more effective and sophisticated therapies.
  • Further research into PCSC biology is essential for advancing prostate cancer treatment.