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Updated: Oct 9, 2025

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
Published on: December 9, 2022
Generation of induced pluripotent stem cell line (ZZUi015-A) from a DM1 patient with cataract
Tingting Li1, Huifang Sun2, Zhuoya Wang3
1Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Abstract:
Myotonic dystrophy (DM1) is mainly caused by abnormal number of the CTG repeat sequence of the DMPK gene. DM1 clinically manifests mainly as progressive muscular atrophy and muscle weakness. Cataracts form in the eyes of some patients. We successfully induced skin fibroblasts from a DM1 patient with cataract and in turn induced pluripotent stem cells (iPSCs) using an unintegrated reprogramming approach. This cell line will provide a reliable cell model for further studies on the pathogenesis and potential therapeutic targets of DM1.
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