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Associations between tumor and edema volumes with tumor infiltrating lymphocytes in brain metastasis - A preliminary
Hans-Jonas Meyer1, Anne-Kathrin Höhn2, Gordian Prasse3
1Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.
Objective:
Perifocal edema of brain tumors is associated with survival and neurological symptoms. The present study sought to elucidate the association between edema volume and tumor infiltrating lymphocytes (TIL) in brain metastasis.
Methods:
25 patients with brain metastasis were included into the retrospective study. TILs expressing CD45 was analyzed with leucocyte common antigen staining. MRI was used to semiautomatically estimate tumor and edema volumes.
Results:
No correlation between tumor volume and edema volume was identified. A positive correlation was identified between tumor volume and TILs expressing CD45 of the stromal compartment (r = 0.46, p = 0.02). No correlations were identified between TILs expressing CD45 and edema volume.
Conclusions:
The present study identified correlations between TILs expressing CD45 and volume of BM. The tumor growth of BM might lead to a recruitment of TIL, which could be assessed by MRI.
