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Related Experiment Videos

Complement activation in bronchial asthma evaluated by the C3d/C3 index.

O Michel, R Sergysels, J Duchateau

    Annals of Allergy
    |December 1, 1986
    PubMed
    Summary

    Complement activation, indicated by higher C3d levels and C3d/C3 ratios, was observed in adults with bronchial asthma. Some asthmatics showed classical complement pathway activation, but clinical significance remains unclear.

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    Area of Science:

    • Immunology
    • Pulmonology
    • Biochemistry

    Background:

    • Bronchial asthma is a chronic respiratory disease.
    • The complement system plays a role in immune responses.
    • Complement activation may be implicated in asthma pathogenesis.

    Purpose of the Study:

    • To investigate complement activation in bronchial asthma.
    • To measure C3d and C3d/C3 ratio as markers of complement activation.
    • To explore potential differences in complement activation pathways in asthmatics.

    Main Methods:

    • Measured C3d and C3d/C3 ratio in 73 adult asthmatics and 47 healthy controls.
    • Assessed C4 plasmatic levels in asthmatic subjects.
    • Analyzed clinical, allergologic, and respiratory functional parameters.

    Main Results:

    • Asthmatic subjects exhibited significantly higher C3d levels and C3d/C3 ratios compared to controls.
    • Fourteen asthmatics showed elevated C3d/C3 ratios, with significantly lower C4 levels, suggesting classical pathway activation.
    • No significant differences in clinical or functional parameters were found between asthmatics with low or high C3d/C3 index.

    Conclusions:

    • Complement activation, potentially via the classical pathway, is present in some individuals with bronchial asthma.
    • The clinical relevance of observed complement activation markers in asthma requires further investigation.
    • Current findings do not correlate complement activation levels with clinical asthma severity or functional parameters.

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